A Single Nucleotide Polymorphism in Osteonectin 3′ Untranslated Region Regulates Bone Volume and Is Targeted by miR-433
نویسندگان
چکیده
منابع مشابه
A single nucleotide polymorphism in osteonectin 3' untranslated region regulates bone volume and is targeted by miR-433.
Osteonectin/SPARC is one of the most abundant noncollagenous extracellular matrix proteins in bone, regulating collagen fiber assembly and promoting osteoblast differentiation. Osteonectin-null and haploinsufficient mice have low-turnover osteopenia, indicating that osteonectin contributes to normal bone formation. In male idiopathic osteoporosis patients, osteonectin 3' untranslated region (UT...
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ژورنال
عنوان ژورنال: Journal of Bone and Mineral Research
سال: 2015
ISSN: 0884-0431
DOI: 10.1002/jbmr.2378